A Recombinant Measles Virus Unable To Antagonize STAT1 Function Cannot Control Inflammation and Is Attenuated in Rhesus Monkeys

Measles remains a leading cause of death worldwide among children because it suppresses immune function. The measles virus (MV) P gene encodes three proteins (P, V, and C) that interfere with innate immunity, controlling STAT1, STAT2, mda5, and perhaps other key regulators of immune function. We ide...

Full description

Saved in:
Bibliographic Details
Main Authors: Devaux, Patricia, Hudacek, Andrew W., Hodge, Gregory, Reyes-del Valle, Jorge, McChesney, Michael B., Cattaneo, Roberto
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2011
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014164/
https://ncbi.nlm.nih.gov/pubmed/20980517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00802-10
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items