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A Recombinant Measles Virus Unable To Antagonize STAT1 Function Cannot Control Inflammation and Is Attenuated in Rhesus Monkeys

Measles remains a leading cause of death worldwide among children because it suppresses immune function. The measles virus (MV) P gene encodes three proteins (P, V, and C) that interfere with innate immunity, controlling STAT1, STAT2, mda5, and perhaps other key regulators of immune function. We ide...

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Autori principali: Devaux, Patricia, Hudacek, Andrew W., Hodge, Gregory, Reyes-del Valle, Jorge, McChesney, Michael B., Cattaneo, Roberto
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014164/
https://ncbi.nlm.nih.gov/pubmed/20980517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00802-10
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