Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

The reasons for inadequate production of erythropoietin (EPO) in patients with ESRD are poorly understood. A better understanding of EPO regulation, namely oxygen-dependent hydroxylation of the hypoxia-inducible transcription factor (HIF), may enable targeted pharmacological intervention. Here, we t...

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Hlavní autoři: Bernhardt, Wanja M., Wiesener, Michael S., Scigalla, Paul, Chou, James, Schmieder, Roland E., Günzler, Volkmar, Eckardt, Kai-Uwe
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2010
Témata:
Clinical Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014028/
https://ncbi.nlm.nih.gov/pubmed/21115615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010010116
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