SPAK-Knockout Mice Manifest Gitelman Syndrome and Impaired Vasoconstriction

Polymorphisms in the gene encoding sterile 20/SPS1-related proline/alanine-rich kinase (SPAK) associate with hypertension susceptibility in humans. SPAK interacts with WNK kinases to regulate the Na(+)-K(+)-2Cl(−) and Na(+)-Cl(−) co-transporters [collectively, N(K)CC]. Mutations in WNK1/4 and N(K)CC...

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Bibliographische Detailangaben
Hauptverfasser: Yang, Sung-Sen, Lo, Yi-Fen, Wu, Chin-Chen, Lin, Shu-Wha, Yeh, Chien-Ju, Chu, Pauling, Sytwu, Huey-Kang, Uchida, Shinichi, Sasaki, Sei, Lin, Shih-Hua
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2010
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014002/
https://ncbi.nlm.nih.gov/pubmed/20813865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009121295
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