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Destabilization of Ca(2+)-free gelsolin may not be responsible for proteolysis in Familial Amyloidosis of Finnish Type

Mutations at position 187 in secreted gelsolin enable aberrant proteolysis at the 172–173 and 243–244 amide bonds, affording the 71-residue amyloidogenic peptide deposited in Familial Amyloidosis of Finnish Type (FAF). Thermodynamic comparisons of two different domain 2 constructs were carried out t...

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Détails bibliographiques
Auteurs principaux: Ratnaswamy, Gayathri, Huff, Mary E., Su, Andrew I., Rion, Severine, Kelly, Jeffery W.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 2001
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC30139/
https://ncbi.nlm.nih.gov/pubmed/11226240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.041452598
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