Heme Oxygenase-1 Inhibits Renal Tubular Macroautophagy in Acute Kidney Injury

Autophagy is a tightly regulated, programmed mechanism to eliminate damaged organelles and proteins from a cell to maintain homeostasis. Cisplatin, a chemotherapeutic agent, accumulates in the proximal tubules of the kidney and causes dose-dependent nephrotoxicity, which may involve autophagy. In th...

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Autores principales: Bolisetty, Subhashini, Traylor, Amie M., Kim, Junghyun, Joseph, Reny, Ricart, Karina, Landar, Aimee, Agarwal, Anupam
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Nephrology 2010
Materias:
Basic Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013546/
https://ncbi.nlm.nih.gov/pubmed/20705711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010030238
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