Activation of NFAT Signaling in Podocytes Causes Glomerulosclerosis

Mutant forms of TRPC6 can activate NFAT-dependent transcription in vitro via calcium influx and activation of calcineurin. The same TRPC6 mutants can cause FSGS, but whether this involves an NFAT-dependent mechanism is unknown. Here, we generated mice that allow conditional induction of NFATc1. Mice...

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Autors principals: Wang, Yinqiu, Jarad, George, Tripathi, Piyush, Pan, Minggui, Cunningham, Jeanette, Martin, Daniel R., Liapis, Helen, Miner, Jeffrey H., Chen, Feng
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2010
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013542/
https://ncbi.nlm.nih.gov/pubmed/20651158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009121253
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