Podocyte-Specific Deletion of Dicer Alters Cytoskeletal Dynamics and Causes Glomerular Disease

MicroRNAs (miRNAs) regulate gene expression by binding the 3′ untranslated region of mRNAs. To define their role in glomerular function, miRNA biogenesis was disrupted in mouse podocytes using a conditional Dicer allele. Mutant mice developed proteinuria by 3 wk after birth and progressed rapidly to...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Harvey, Scott J., Jarad, George, Cunningham, Jeanette, Goldberg, Seth, Schermer, Bernhard, Harfe, Brian D., McManus, Michael T., Benzing, Thomas, Miner, Jeffrey H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Nephrology 2008
Aiheet:
Basic Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573015/
https://ncbi.nlm.nih.gov/pubmed/18776121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008020233
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia