Podocyte-Specific Deletion of Dicer Alters Cytoskeletal Dynamics and Causes Glomerular Disease

MicroRNAs (miRNAs) regulate gene expression by binding the 3′ untranslated region of mRNAs. To define their role in glomerular function, miRNA biogenesis was disrupted in mouse podocytes using a conditional Dicer allele. Mutant mice developed proteinuria by 3 wk after birth and progressed rapidly to...

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Detalhes bibliográficos
Main Authors: Harvey, Scott J., Jarad, George, Cunningham, Jeanette, Goldberg, Seth, Schermer, Bernhard, Harfe, Brian D., McManus, Michael T., Benzing, Thomas, Miner, Jeffrey H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2008
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573015/
https://ncbi.nlm.nih.gov/pubmed/18776121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008020233
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