Duplicated Gephyrin Genes Showing Distinct Tissue Distribution and Alternative Splicing Patterns Mediate Molybdenum Cofactor Biosynthesis, Glycine Receptor Clustering, and Escape Behavior in Zebrafish

Gephyrin mediates the postsynaptic clustering of glycine receptors (GlyRs) and GABA(A) receptors at inhibitory synapses and molybdenum-dependent enzyme (molybdoenzyme) activity in non-neuronal tissues. Gephyrin knock-out mice show a phenotype resembling both defective glycinergic transmission and mo...

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Hauptverfasser: Ogino, Kazutoyo, Ramsden, Sarah L., Keib, Natalie, Schwarz, Günter, Harvey, Robert J., Hirata, Hiromi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013040/
https://ncbi.nlm.nih.gov/pubmed/20843816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.125500
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