Negative Regulation of EGFR-Vav2 Signaling Axis by Cbl Ubiquitin Ligase Controls EGF Receptor-mediated Epithelial Cell Adherens Junction Dynamics and Cell Migration

The E3 ubiquitin ligase Casitas B lymphoma protein (Cbl) controls the ubiquitin-dependent degradation of EGF receptor (EGFR), but its role in regulating downstream signaling elements with which it associates and its impact on biological outcomes of EGFR signaling are less clear. Here, we demonstrate...

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Hlavní autoři: Duan, Lei, Raja, Srikumar M., Chen, Gengsheng, Virmani, Sumeet, Williams, Stetson H., Clubb, Robert J., Mukhopadhyay, Chandrani, Rainey, Mark A., Ying, Guoguang, Dimri, Manjari, Chen, Jing, Reddi, Alagarsamy L., Naramura, Mayumi, Band, Vimla, Band, Hamid
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013022/
https://ncbi.nlm.nih.gov/pubmed/20940296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.188086
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