TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage

Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand break via a 5′-phosphotyrosyl bond. Although these intermediates are normally transient, they can be stabilized by antitumor agents that act as Top2 “poisons,” resulting in...

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Detalles Bibliográficos
Main Authors: Zeng, Zhihong, Cortés-Ledesma, Felipe, El Khamisy, Sherif F., Caldecott, Keith W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012998/
https://ncbi.nlm.nih.gov/pubmed/21030584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.181016
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