Lysophosphatidic Acid Induces MDA-MB-231 Breast Cancer Cells Migration through Activation of PI3K/PAK1/ERK Signaling

BACKGROUND: Enhanced motility of cancer cells is a critical step in promoting tumor metastasis. Lysophosphatidic acid (LPA), representing the major mitogenic activity in serum, stimulates migration in various types of cancer cells. However, the underlying signaling mechanisms for LPA-induced motilit...

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Main Authors: Du, Jun, Sun, Chongqi, Hu, Zhenzhen, Yang, Yu, Zhu, Yichao, Zheng, Datong, Gu, Luo, Lu, Xiang
格式: Artigo
語言:Inglês
出版: Public Library of Science 2010
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012724/
https://ncbi.nlm.nih.gov/pubmed/21209852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015940
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