Definition of the intermediates and mechanism of the anticancer drug bleomycin using nuclear resonance vibrational spectroscopy and related methods

Bleomycin (BLM) is a glycopeptide anticancer drug capable of effecting single- and double-strand DNA cleavage. The last detectable intermediate prior to DNA cleavage is a low spin Fe(III) peroxy level species, termed activated bleomycin (ABLM). DNA strand scission is initiated through the abstractio...

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Detalhes bibliográficos
Main Authors: Liu, Lei V., Bell, Caleb B., Wong, Shaun D., Wilson, Samuel A., Kwak, Yeonju, Chow, Marina S., Zhao, Jiyong, Hodgson, Keith O., Hedman, Britt, Solomon, Edward I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012509/
https://ncbi.nlm.nih.gov/pubmed/21149675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016323107
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