Downregulation of Adipose Tissue Fatty Acid Trafficking in Obesity: A Driver for Ectopic Fat Deposition?

OBJECTIVE: Lipotoxicity and ectopic fat deposition reduce insulin signaling. It is not clear whether excess fat deposition in nonadipose tissue arises from excessive fatty acid delivery from adipose tissue or from impaired adipose tissue storage of ingested fat. RESEARCH DESIGN AND METHODS: To inves...

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Hauptverfasser: McQuaid, Siobhán E., Hodson, Leanne, Neville, Matthew J., Dennis, A. Louise, Cheeseman, Jane, Humphreys, Sandy M., Ruge, Toralph, Gilbert, Marjorie, Fielding, Barbara A., Frayn, Keith N., Karpe, Fredrik
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2011
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012196/
https://ncbi.nlm.nih.gov/pubmed/20943748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0867
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