The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm.

In Saccharomyces cerevisiae the UPF1 protein is required for nonsense-mediated mRNA decay, the accelerated turnover of mRNAs containing a nonsense mutation. Several lines of evidence suggest that translation plays an important role in the mechanism of nonsense mRNA decay, including a previous report...

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Publié dans:	Mol Biol Cell
Auteurs principaux:	Atkin, A L, Altamura, N, Leeds, P, Culbertson, M R
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Cell Biology 1995
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC301219/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7545033/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.6.5.611
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