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The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm.

In Saccharomyces cerevisiae the UPF1 protein is required for nonsense-mediated mRNA decay, the accelerated turnover of mRNAs containing a nonsense mutation. Several lines of evidence suggest that translation plays an important role in the mechanism of nonsense mRNA decay, including a previous report...

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Furkejuvvon:
Bibliográfalaš dieđut
Publikašuvnnas:Mol Biol Cell
Váldodahkkit: Atkin, A L, Altamura, N, Leeds, P, Culbertson, M R
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: American Society for Cell Biology 1995
Fáttát:
Liŋkkat:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC301219/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7545033/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.6.5.611
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