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Diminished Superoxide Generation Is Associated With Respiratory Chain Dysfunction and Changes in the Mitochondrial Proteome of Sensory Neurons From Diabetic Rats

OBJECTIVE: Impairments in mitochondrial function have been proposed to play a role in the etiology of diabetic sensory neuropathy. We tested the hypothesis that mitochondrial dysfunction in axons of sensory neurons in type 1 diabetes is due to abnormal activity of the respiratory chain and an altere...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Akude, Eli, Zherebitskaya, Elena, Chowdhury, Subir K. Roy, Smith, Darrell R., Dobrowsky, Rick T., Fernyhough, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012184/
https://ncbi.nlm.nih.gov/pubmed/20876714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0818
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