Exendin-4 Suppresses Src Activation and Reactive Oxygen Species Production in Diabetic Goto-Kakizaki Rat Islets in an Epac-Dependent Manner

OBJECTIVE: Reactive oxygen species (ROS) is one of most important factors in impaired metabolism secretion coupling in pancreatic β-cells. We recently reported that elevated ROS production and impaired ATP production at high glucose in diabetic Goto-Kakizaki (GK) rat islets are effectively ameliorat...

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Bibliografiske detaljer
Main Authors: Mukai, Eri, Fujimoto, Shimpei, Sato, Hiroki, Oneyama, Chitose, Kominato, Rieko, Sato, Yuichi, Sasaki, Mayumi, Nishi, Yuichi, Okada, Masato, Inagaki, Nobuya
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2011
Fag:
Islet Studies
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012174/
https://ncbi.nlm.nih.gov/pubmed/20978090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0021
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