Reduction of Reactive Oxygen Species Ameliorates Metabolism-Secretion Coupling in Islets of Diabetic GK Rats by Suppressing Lactate Overproduction

We previously demonstrated that impaired glucose-induced insulin secretion (IS) and ATP elevation in islets of Goto-Kakizaki (GK) rats, a nonobese model of diabetes, were significantly restored by 30–60-min suppression of endogenous reactive oxygen species (ROS) overproduction. In this study, we inv...

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Detalhes bibliográficos
Main Authors: Sasaki, Mayumi, Fujimoto, Shimpei, Sato, Yuichi, Nishi, Yuichi, Mukai, Eri, Yamano, Gen, Sato, Hiroki, Tahara, Yumiko, Ogura, Kasane, Nagashima, Kazuaki, Inagaki, Nobuya
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661648/
https://ncbi.nlm.nih.gov/pubmed/23349483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0903
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