Inactivation of the FLCN Tumor Suppressor Gene Induces TFE3 Transcriptional Activity by Increasing Its Nuclear Localization

BACKGROUND: Germline mutations in a tumor suppressor gene FLCN lead to development of fibrofolliculomas, lung cysts and renal cell carcinoma (RCC) in Birt-Hogg-Dubé syndrome. TFE3 is a member of the MiTF/TFE transcription factor family and Xp11.2 translocations found in sporadic RCC involving TFE3 r...

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Main Authors: Hong, Seung-Beom, Oh, HyoungBin, Valera, Vladimir A., Baba, Masaya, Schmidt, Laura S., Linehan, W. Marston
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012117/
https://ncbi.nlm.nih.gov/pubmed/21209915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015793
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