Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-β signaling

BACKGROUND: Germline mutations in the FLCN gene are responsible for the development of fibrofolliculomas, lung cysts and renal neoplasia in Birt-Hogg-Dube' (BHD) syndrome. The encoded protein folliculin (FLCN) is conserved across species but contains no classic motifs or domains and its functio...

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Hauptverfasser: Hong, Seung-Beom, Oh, HyoungBin, Valera, Vladimir A, Stull, Jaime, Ngo, Duy-Tan, Baba, Masaya, Merino, Maria J, Linehan, W Marston, Schmidt, Laura S
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907329/
https://ncbi.nlm.nih.gov/pubmed/20573232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-160
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