A Systematic Enhancer Screen Using Lentivector Transgenesis Identifies Conserved and Non-Conserved Functional Elements at the Olig1 and Olig2 Locus

Finding sequences that control expression of genes is central to understanding genome function. Previous studies have used evolutionary conservation as an indicator of regulatory potential. Here, we present a method for the unbiased in vivo screen of putative enhancers in large DNA regions, using th...

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Detalhes bibliográficos
Main Authors: Friedli, Marc, Barde, Isabelle, Arcangeli, Mélanie, Verp, Sonia, Quazzola, Alexandra, Zakany, Jozsef, Lin-Marq, Nathalie, Robyr, Daniel, Attanasio, Catia, Spitz, François, Duboule, Denis, Trono, Didier, Antonarakis, Stylianos E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012086/
https://ncbi.nlm.nih.gov/pubmed/21206754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015741
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