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Solvent effects on the energy landscapes and folding kinetics of polyalanine

The effect of a solvation on the thermodynamics and kinetics of polyalanine (Ala(12)) is explored on the basis of its energy landscapes in vacuum and in an aqueous solution. Both energy landscapes are characterized by two basins, one associated with α-helical structures and the other with coil and β...

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Main Authors: Levy, Yaakov, Jortner, Joshua, Becker, Oren M.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC30113/
https://ncbi.nlm.nih.gov/pubmed/11226214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.041611998
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