Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins
Large-scale motions of biomolecules involve linear elastic deformations along low-frequency normal modes, but for function nonlinearity is essential. In addition, unlike macroscopic machines, biological machines can locally break and then reassemble during function. We present a model for global str...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240658/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14566052/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2135471100 |
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