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A new preclinical biomarker for risk of Torsades de Pointes: drug-induced reduction of the cardiac electromechanical window
Evaluation of new therapeutic agents for their potential to cause QT interval prolongation and drug-induced ventricular arrhythmia, like Torsades de Pointes (TdP), is a critical activity during drug development. The QT interval has been used as a surrogate biomarker to assess ventricular repolarizat...
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| Auteur principal: | |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Blackwell Science Inc
2010
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3010557/ https://ncbi.nlm.nih.gov/pubmed/20698854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00980.x |
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