A new preclinical biomarker for risk of Torsades de Pointes: drug-induced reduction of the cardiac electromechanical window

Por Vargas, Hugo M
Publicado em 2010

Oxytocin does not directly alter cardiac repolarization in rabbit or human cardiac myocytes

Por Qu, Yusheng, Fang, Mei, Gao, BaoXi, Amagasu, Shanti, Crumb, William J, Vargas, Hugo M
Publicado no Pharmacol Res Perspect (2015)

Action Potential Recording and Pro-arrhythmia Risk Analysis in Human Ventricular Trabeculae

Por Qu, Yusheng, Page, Guy, Abi-Gerges, Najah, Miller, Paul E., Ghetti, Andre, Vargas, Hugo M.
Publicado no Front Physiol (2018)

Evaluation of drug-induced QT interval prolongation in animal and human studies: a literature review of concordance

Por Vargas, Hugo M, Bass, Alan S, Koerner, John, Matis-Mitchell, Sherri, Pugsley, Michael K, Skinner, Matthew, Burnham, Matthew, Bridgland-Taylor, Matthew, Pettit, Syril, Valentin, Jean-Pierre
Publicado no Br J Pharmacol (2015)

Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D

Por Low, Jonathan D., Bartberger, Michael D., Chen, Kui, Cheng, Yuan, Fielden, Mark R., Gore, Vijay, Hickman, Dean, Liu, Qingyian, Allen Sickmier, E., Vargas, Hugo M., Werner, Jonathan, White, Ryan D., Whittington, Douglas A., Wood, Stephen, Minatti, Ana E.
Publicado no Medchemcomm (2017)

Benzofuran Derivatives as Potent, Orally Active S1P(1) Receptor Agonists: A Preclinical Lead Molecule for MS

Por Saha, Ashis K., Yu, Xiang, Lin, Jian, Lobera, Mercedes, Sharadendu, Anurag, Chereku, Srinivas, Schutz, Nili, Segal, Dalia, Marantz, Yael, McCauley, Dilara, Middleton, Scot, Siu, Jerry, Bürli, Roland W., Buys, Janet, Horner, Michelle, Salyers, Kevin, Schrag, Michael, Vargas, Hugo M., Xu, Yang, McElvain, Michele, Xu, Han
Publicado em 2010

Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P(1) and S1P(5)

Por Cee, Victor J., Frohn, Mike, Lanman, Brian A., Golden, Jennifer, Muller, Kristine, Neira, Susana, Pickrell, Alex, Arnett, Heather, Buys, Janet, Gore, Anu, Fiorino, Mike, Horner, Michelle, Itano, Andrea, Lee, Matt R., McElvain, Michele, Middleton, Scot, Schrag, Michael, Rivenzon-Segal, Dalia, Vargas, Hugo M., Xu, Han, Xu, Yang, Zhang, Xuxia, Siu, Jerry, Wong, Min, Bürli, Roland W.
Publicado em 2010

An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities

Por Cheng, Yuan, Brown, James, Judd, Ted C., Lopez, Patricia, Qian, Wenyuan, Powers, Timothy S., Chen, Jian Jeffrey, Bartberger, Michael D., Chen, Kui, Dunn, Robert T., Epstein, Oleg, Fremeau, Robert T., Harried, Scott, Hickman, Dean, Hitchcock, Stephen A., Luo, Yi, Minatti, Ana Elena, Patel, Vinod F., Vargas, Hugo M., Wahl, Robert C., Weiss, Matthew M., Wen, Paul H., White, Ryan D., Whittington, Douglas A., Zheng, Xiao Mei, Wood, Stephen
Publicado no ACS Med Chem Lett (2014)

Discovery of a Potent, S1P(3)-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P(1))

Por Lanman, Brian A., Cee, Victor J., Cheruku, Srinivasa R., Frohn, Mike, Golden, Jennifer, Lin, Jian, Lobera, Mercedes, Marantz, Yael, Muller, Kristine M., Neira, Susana C., Pickrell, Alexander J., Rivenzon-Segal, Dalia, Schutz, Nili, Sharadendu, Anurag, Yu, Xiang, Zhang, Zhaoda, Buys, Janet, Fiorino, Mike, Gore, Anu, Horner, Michelle, Itano, Andrea, McElvain, Michele, Middleton, Scot, Schrag, Michael, Vargas, Hugo M., Xu, Han, Xu, Yang, Zhang, Xuxia, Siu, Jerry, Bürli, Roland W.
Publicado em 2010