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Discovery of a Potent, S1P(3)-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P(1))
[Image: see text] Optimization of a benzofuranyl S1P(1) agonist lead compound (3) led to the discovery of 1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid (14), a potent S1P(1) agonist with minimal activity at S1P(3). Dosed orally at 0.3 mg/kg, 14 significantl...
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Chemical Society
2010
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4018108/ https://ncbi.nlm.nih.gov/pubmed/24900287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100228m |
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