Comparative analysis of pyrosequencing and QMC-PCR in conjunction with high resolution melting for KRAS/BRAF mutation detection

To compare the limit of detection (LOD), mutations in KRAS (codon 12/13 hotspot) and BRAF (V600E hotspot) were tested. DNA mixtures containing mutant alleles at a frequency of around 25%/12.5%/6%/3%/ 1.5%/0.8% were analysed. To compare frequency of mutation detection, 22 DNA samples (nine high quali...

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Detalhes bibliográficos
Main Authors: Ibrahem, Salih, Seth, Rashmi, O'Sullivan, Brendan, Fadhil, Wakkas, Taniere, Philippe, Ilyas, Mohammad
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010548/
https://ncbi.nlm.nih.gov/pubmed/21199003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2613.2010.00733.x
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