UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells

DNA double strand breaks (DSB) may be caused by ionizing radiation. In contrast, UV exposure forms dipyrimidine photoproducts and is not considered an inducer of DSB. We found that uniform or localized UV treatment induced phosphorylation of the DNA damage related (DDR) proteins H2AX, ATM and NBS1 a...

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Huvudupphovsmän: Oh, Kyu-Seon, Bustin, Michael, Mazur, Sharlyn J., Appella, Ettore, Kraemer, Kenneth H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010519/
https://ncbi.nlm.nih.gov/pubmed/20947453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.09.004
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