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The Efavirenz Binding Site in HIV-1 Reverse Transcriptase Monomers
Efavirenz (EFV) is a potent nonnucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of AIDS. NNRTIs bind in a hydrophobic pocket located in the p66 subunit of reverse transcriptase (RT), which is not present in crystal structures of RT without inhibitor. Recent studies showed tha...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3010390/ https://ncbi.nlm.nih.gov/pubmed/21090588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101480z |
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