Ca(2+) spark-dependent and -independent sarcoplasmic reticulum Ca(2+) leak in normal and failing rabbit ventricular myocytes

Sarcoplasmic reticulum (SR) Ca(2+) leak is an important component of cardiac Ca(2+) signalling. Together with the SR Ca(2+)-ATPase (SERCA)-mediated Ca(2+) uptake, diastolic Ca(2+) leak determines SR Ca(2+) load and, therefore, the amplitude of Ca(2+) transients that initiate contraction. Spontaneous...

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Bibliographische Detailangaben
Hauptverfasser: Zima, Aleksey V, Bovo, Elisa, Bers, Donald M, Blatter, Lothar A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2010
Schlagworte:
Cardiovascular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010143/
https://ncbi.nlm.nih.gov/pubmed/20962003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.197913
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