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mRNA turnover rate limits siRNA and microRNA efficacy

The microRNA pathway participates in basic cellular processes and its discovery has enabled the development of si/shRNAs as powerful investigational tools and potential therapeutics. Based on a simple kinetic model of the mRNA life cycle, we hypothesized that mRNAs with high turnover rates may be mo...

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Bibliografiske detaljer
Main Authors: Larsson, Erik, Sander, Chris, Marks, Debora
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010119/
https://ncbi.nlm.nih.gov/pubmed/21081925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2010.89
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