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mRNA turnover rate limits siRNA and microRNA efficacy
The microRNA pathway participates in basic cellular processes and its discovery has enabled the development of si/shRNAs as powerful investigational tools and potential therapeutics. Based on a simple kinetic model of the mRNA life cycle, we hypothesized that mRNAs with high turnover rates may be mo...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3010119/ https://ncbi.nlm.nih.gov/pubmed/21081925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2010.89 |
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