mRNA turnover rate limits siRNA and microRNA efficacy
Abstract The microRNA pathway participates in basic cellular processes and its discovery has enabled the development of si/shRNAs as powerful investigational tools and potential therapeutics. Based on a simple kinetic model of the mRNA life cycle, we hypothesized that mRNAs with high turnover rates...
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| Principais autores: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer Nature
2010-11-01
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| Serier: | Molecular Systems Biology |
| Fag: | |
| Online adgang: | https://doi.org/10.1038/msb.2010.89 |
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