mRNA turnover rate limits siRNA and microRNA efficacy
Abstract The microRNA pathway participates in basic cellular processes and its discovery has enabled the development of si/shRNAs as powerful investigational tools and potential therapeutics. Based on a simple kinetic model of the mRNA life cycle, we hypothesized that mRNAs with high turnover rates...
保存先:
| 主要な著者: | , , |
|---|---|
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer Nature
2010-11-01
|
| シリーズ: | Molecular Systems Biology |
| 主題: | |
| オンライン･アクセス: | https://doi.org/10.1038/msb.2010.89 |
| タグ: |
タグなし, このレコードへの初めてのタグを付けませんか!
|