mRNA turnover rate limits siRNA and microRNA efficacy
Abstract The microRNA pathway participates in basic cellular processes and its discovery has enabled the development of si/shRNAs as powerful investigational tools and potential therapeutics. Based on a simple kinetic model of the mRNA life cycle, we hypothesized that mRNAs with high turnover rates...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Springer Nature
2010-11-01
|
| Colección: | Molecular Systems Biology |
| Materias: | |
| Acceso en línea: | https://doi.org/10.1038/msb.2010.89 |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|