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Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories
Replication origins are licensed by loading MCM2-7 hexamers before entry into S phase. However, only ∼10% of licensed origins are normally used in S phase, with the others remaining dormant. When fork progression is inhibited, dormant origins initiate nearby to ensure that all of the DNA is eventual...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3010067/ https://ncbi.nlm.nih.gov/pubmed/21173116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201007074 |
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