Muscle weakness in Ryr1(I4895T/WT) knock-in mice as a result of reduced ryanodine receptor Ca(2+) ion permeation and release from the sarcoplasmic reticulum

The type 1 isoform of the ryanodine receptor (RYR1) is the Ca(2+) release channel of the sarcoplasmic reticulum (SR) that is activated during skeletal muscle excitation–contraction (EC) coupling. Mutations in the RYR1 gene cause several rare inherited skeletal muscle disorders, including malignant h...

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Huvudupphovsmän: Loy, Ryan E., Orynbayev, Murat, Xu, Le, Andronache, Zoita, Apostol, Simona, Zvaritch, Elena, MacLennan, David H., Meissner, Gerhard, Melzer, Werner, Dirksen, Robert T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010056/
https://ncbi.nlm.nih.gov/pubmed/21149547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201010523
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