P0 (Protein Zero) Mutation S34C Underlies Instability of Internodal Myelin in S63C Mice

P0 constitutes 50–60% of protein in peripheral nerve myelin and is essential for its structure and stability. Mutations within the P0 gene (MPZ) underlie a variety of hereditary neuropathies. MpzS63C transgenic mice encode a P0 with a serine to cysteine substitution at position 34 in the extracellul...

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Main Authors: Avila, Robin L., D'Antonio, Maurizio, Bachi, Angela, Inouye, Hideyo, Feltri, M. Laura, Wrabetz, Lawrence, Kirschner, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Neurobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009926/
https://ncbi.nlm.nih.gov/pubmed/20937820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.166967
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