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Natural and Engineered Photoactivated Nucleotidyl Cyclases for Optogenetic Applications
Cyclic nucleotides, cAMP and cGMP, are ubiquitous second messengers that regulate metabolic and behavioral responses in diverse organisms. We describe purification, engineering, and characterization of photoactivated nucleotidyl cyclases that can be used to manipulate cAMP and cGMP levels in vivo. W...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3009876/ https://ncbi.nlm.nih.gov/pubmed/21030591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.177600 |
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