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Ser(120) of Ubc2/Rad6 Regulates Ubiquitin-dependent N-end Rule Targeting by E3α/Ubr1
In CHO cells, CDK1/2-dependent phosphorylation of Ubc2/Rad6 at Ser(120) stimulates its ubiquitin conjugating activity and can be replicated by a S120D point mutant (Sarcevic, B., Mawson, A., Baker, R. T., and Sutherland, R. L. (2002) EMBO J. 21, 2009–2018). In contrast, we find that ectopic expressi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3009855/ https://ncbi.nlm.nih.gov/pubmed/21041297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.169136 |
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