Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells

The G protein-coupled receptor (GPCR), chemokine CXC-type receptor 4 (CXCR4), and its ligand, CXCL12, mediate the retention of polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) in the bone marrow. Agents that disrupt CXCL12-mediated chemoattraction of CXCR4-exp...

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Bibliografiske detaljer
Main Authors: Tchernychev, Boris, Ren, Yong, Sachdev, Pallavi, Janz, Jay M., Haggis, Lynn, O'Shea, Adam, McBride, Ed, Looby, Richard, Deng, Qing, McMurry, Thomas, Kazmi, Manija A., Sakmar, Thomas P., Hunt, Stephen, Carlson, Kenneth E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009824/
https://ncbi.nlm.nih.gov/pubmed/21139054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009633108
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