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Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair

Ig class-switch recombination (CSR) is a region-specific process that exchanges the constant Ig heavy-chain region and thus modifies an antibody's effector function. DNA lesions in switch (S) regions are induced by activation-induced cytidine deaminase (AID) and uracil-DNA glycosylase 2 (UNG2),...

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書誌詳細
主要な著者: Kracker, Sven, Imai, Kohsuke, Gardès, Pauline, Ochs, Hans D., Fischer, Alain, Durandy, Anne H.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009794/
https://ncbi.nlm.nih.gov/pubmed/21135220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012591108
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