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Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair
Ig class-switch recombination (CSR) is a region-specific process that exchanges the constant Ig heavy-chain region and thus modifies an antibody's effector function. DNA lesions in switch (S) regions are induced by activation-induced cytidine deaminase (AID) and uracil-DNA glycosylase 2 (UNG2),...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3009794/ https://ncbi.nlm.nih.gov/pubmed/21135220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012591108 |
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