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Kinetics of chain motions within a protein-folding intermediate

Small proteins can fold remarkably rapidly, even in μs. What limits their rate of folding? The Engrailed homeodomain is a particularly well-characterized example, which folds ultrafast via an intermediate, I, of solved structure. It is a puzzle that the helix2-turn-helix3 motif of the 3-helix bundle...

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Detalhes bibliográficos
Main Authors: Neuweiler, Hannes, Banachewicz, Wiktor, Fersht, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009767/
https://ncbi.nlm.nih.gov/pubmed/21135210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011666107
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