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Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β-sheet

The rat α7 nicotinic acetylcholine receptor (nAChR) has a proline residue near the middle of the β9 strand. The replacement of this proline residue at position 180 (P180) by either threonine (α7-P180T) or serine (α7-P180S) slowed the onset of desensitization dramatically, with half-times of ∼930 and...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: McCormack, Thomas J, Melis, Claudio, Colón, José, Gay, Elaine A, Mike, Arpad, Karoly, Robert, Lamb, Patricia W, Molteni, Carla, Yakel, Jerrel L
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Blackwell Science Inc 2010
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008848/
https://ncbi.nlm.nih.gov/pubmed/20837638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.195495
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