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Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel opening

Nicotinic acetylcholine receptors (nAChRs) are in the superfamily of Cys-loop ligand-gated ion channels, and are pentameric assemblies of five subunits, with each subunit arranged around the central ion-conducting pore. The binding of ACh to the extracellular interface between two subunits induces c...

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Bibliografiske detaljer
Main Authors: Gay, Elaine A, Yakel, Jerrel L
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276999/
https://ncbi.nlm.nih.gov/pubmed/17823204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.142554
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