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Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel opening
Nicotinic acetylcholine receptors (nAChRs) are in the superfamily of Cys-loop ligand-gated ion channels, and are pentameric assemblies of five subunits, with each subunit arranged around the central ion-conducting pore. The binding of ACh to the extracellular interface between two subunits induces c...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Science Inc
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2276999/ https://ncbi.nlm.nih.gov/pubmed/17823204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.142554 |
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