Maltose-Binding Protein Enhances Secretion of Recombinant Human Granzyme B Accompanied by In Vivo Processing of a Precursor MBP Fusion Protein

BACKGROUND: The apoptosis-inducing serine protease granzyme B (GrB) is an important factor contributing to lysis of target cells by cytotoxic lymphocytes. Expression of enzymatically active GrB in recombinant form is a prerequisite for functional analysis and application of GrB for therapeutic purpo...

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Autores principales: Dälken, Benjamin, Jabulowsky, Robert A., Oberoi, Pranav, Benhar, Itai, Wels, Winfried S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008669/
https://ncbi.nlm.nih.gov/pubmed/21203542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014404
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