Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats

Parathyroid hormone (PTH) is an effective bone anabolic agent, but it must be administered parenterally. An orally active anabolic agent would provide a valuable alternative for treating osteoporosis. NPS 2143 is a novel, selective antagonist (a “calcilytic”) of the parathyroid cell Ca(2+) receptor....

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Detaylı Bibliyografya
Yayımlandı:	J Clin Invest
Asıl Yazarlar:	Gowen, Maxine, Stroup, George B., Dodds, Robert A., James, Ian E., Votta, Bart J., Smith, Brian R., Bhatnagar, Pradip K., Lago, Amparo M., Callahan, James F., DelMar, Eric G., Miller, Michael A., Nemeth, Edward F., Fox, John
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	American Society for Clinical Investigation 2000
Konular:	Article
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC300853/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10841518/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9038
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Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats

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