Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats

Parathyroid hormone (PTH) is an effective bone anabolic agent, but it must be administered parenterally. An orally active anabolic agent would provide a valuable alternative for treating osteoporosis. NPS 2143 is a novel, selective antagonist (a “calcilytic”) of the parathyroid cell Ca(2+) receptor....

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Main Authors: Gowen, Maxine, Stroup, George B., Dodds, Robert A., James, Ian E., Votta, Bart J., Smith, Brian R., Bhatnagar, Pradip K., Lago, Amparo M., Callahan, James F., DelMar, Eric G., Miller, Michael A., Nemeth, Edward F., Fox, John
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2000
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC300853/
https://ncbi.nlm.nih.gov/pubmed/10841518
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