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Loss of DNA polymerase zeta enhances spontaneous tumorigenesis
Mammalian genomes encode at least 15 distinct DNA polymerases, functioning as specialists in DNA replication, DNA repair, recombination, or bypass of DNA damage. Although the DNA pol zeta(ζ) catalytic subunit REV3L is important in defense against genotoxins, little is known of its biological functio...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3008348/ https://ncbi.nlm.nih.gov/pubmed/20215524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4267 |
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