p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis

Clostridium difficile toxin A causes acute neutrophil infiltration and intestinal mucosal injury. In cultured cells, toxin A inactivates Rho proteins by monoglucosylation. In monocytes, toxin A induces IL-8 production and necrosis by unknown mechanisms. We investigated the role of mitogen-activated...

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Pubblicato in:	J Clin Invest
Autori principali:	Warny, Michel, Keates, Andrew C., Keates, Sarah, Castagliuolo, Ignazio, Zacks, Jeff K., Aboudola, Samer, Qamar, Amir, Pothoulakis, Charalabos, LaMont, J. Thomas, Kelly, Ciarán P.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2000
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC300827/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10772660/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI7545
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